Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.

McLeod, Robbie L; Tulshian, Deen B; Bolser, Donald C; Varty, Geoffrey B; Baptista, Marco; Fernandez, Xiomara; Parra, Leonard E; Zimmer, Jennifer C; Erickson, Christine H; Ho, Ginny D; Jia, Yanlin; Ng, Fay W; Korfmacher, Walter; Xu, Xiaoying; Veals, John; Smith-Torhan, April; Wainhaus, Samuel; Fawzi, Ahmad B; Austin, Theodore M; van Heek, Margaret; Hey, John A

McLeod, Robbie L; Tulshian, Deen B; Bolser, Donald C; Varty, Geoffrey B; Baptista, Marco; Fernandez, Xiomara; Parra, Leonard E; Zimmer, Jennifer C; Erickson, Christine H; Ho, Ginny D; Jia, Yanlin; Ng, Fay W; Korfmacher, Walter; Xu, Xiaoying; Veals, John; Smith-Torhan, April; Wainhaus, Samuel; Fawzi, Ahmad B; Austin, Theodore M; van Heek, Margaret; Hey, John A.

Affiliation

McLeod RL; Neurobiology-Respiratory, Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA. robbie.mcleod@spcorp.com <robbie.mcleod@spcorp.com>

Eur J Pharmacol ; 630(1-3): 112-20, 2010 Mar 25.

Article in En | MEDLINE | ID: mdl-20006596

Subject(s)

Antitussive Agents/therapeutic use; Cough/drug therapy; Receptors, Opioid/agonists; Animals; Azabicyclo Compounds/pharmacology; Cats; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Male; Pyrimidines/pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Opioid/metabolism; Nociceptin Receptor

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Full text: 1 Database: MEDLINE Main subject: Antitussive Agents / Receptors, Opioid / Cough Type of study: Evaluation_studies Language: En Journal: Eur J Pharmacol Year: 2010 Type: Article

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