Chemoprevention for colorectal neoplasia.
Clin Colon Rectal Surg
; 21(4): 304-12, 2008 Nov.
Article
in En
| MEDLINE
| ID: mdl-20011443
ABSTRACT
Colorectal cancer is a major cause of morbidity and mortality in industrialized societies and leads to significant treatment costs. Currently there are screening programs with fecal occult blood testing, radiographic, and endoscopic evaluation. Despite this, mortality from colorectal cancer has not improved dramatically. As such, attention has turned to finding agents to prevent carcinogenesis. The emerging field known as chemoprevention studies agents that target multiple steps in the development of adenomas and their subsequent transformation to colorectal carcinoma. There are multiple case control, cohort, and randomized controlled trials investigating the efficacy of fiber, calcium, vitamin D, folate, and nonsteroidal antiinflammatory drugs as chemopreventive agents against colorectal cancer.
Full text:
1
Database:
MEDLINE
Type of study:
Clinical_trials
Language:
En
Journal:
Clin Colon Rectal Surg
Year:
2008
Type:
Article
Affiliation country:
United States