A key role for orexin in panic anxiety.

Johnson, Philip L; Truitt, William; Fitz, Stephanie D; Minick, Pamela E; Dietrich, Amy; Sanghani, Sonal; Träskman-Bendz, Lil; Goddard, Andrew W; Brundin, Lena; Shekhar, Anantha

Johnson, Philip L; Truitt, William; Fitz, Stephanie D; Minick, Pamela E; Dietrich, Amy; Sanghani, Sonal; Träskman-Bendz, Lil; Goddard, Andrew W; Brundin, Lena; Shekhar, Anantha.

Affiliation

Johnson PL; Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Nat Med ; 16(1): 111-5, 2010 Jan.

Article in En | MEDLINE | ID: mdl-20037593

Subject(s)

Intracellular Signaling Peptides and Proteins/physiology; Neuropeptides/physiology; Neurotransmitter Agents/physiology; Panic Disorder/physiopathology; Adult; Alprazolam/pharmacology; Animals; Anxiety/drug therapy; Anxiety/physiopathology; Disease Models, Animal; Female; Humans; Hypothalamus/physiology; Intracellular Signaling Peptides and Proteins/antagonists & inhibitors; Intracellular Signaling Peptides and Proteins/cerebrospinal fluid; Male; Middle Aged; Neurons/drug effects; Neurons/physiology; Neuropeptides/antagonists & inhibitors; Neuropeptides/cerebrospinal fluid; Orexin Receptors; Orexins; Panic Disorder/cerebrospinal fluid; Panic Disorder/drug therapy; Rats; Receptors, G-Protein-Coupled/drug effects; Receptors, G-Protein-Coupled/physiology; Receptors, Neuropeptide/drug effects; Receptors, Neuropeptide/physiology; Sodium Lactate/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Neuropeptides / Panic Disorder / Neurotransmitter Agents / Intracellular Signaling Peptides and Proteins Language: En Journal: Nat Med Year: 2010 Type: Article Affiliation country: United States

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