Curcumin produces an antihyperalgesic effect via antagonism of TRPV1.

Yeon, K Y; Kim, S A; Kim, Y H; Lee, M K; Ahn, D K; Kim, H J; Kim, J S; Jung, S J; Oh, S B

Yeon, K Y; Kim, S A; Kim, Y H; Lee, M K; Ahn, D K; Kim, H J; Kim, J S; Jung, S J; Oh, S B.

Affiliation

Yeon KY; Dental Research Institute and Department of Physiology, Seoul National University, Yeongeon-Dong Chongno-Ku, Korea.

J Dent Res ; 89(2): 170-4, 2010 Feb.

Article in En | MEDLINE | ID: mdl-20040737

Subject(s)

Curcumin/therapeutic use; Facial Pain/drug therapy; Hyperalgesia/drug therapy; Nociceptors/drug effects; TRPV Cation Channels/physiology; Animals; Capsaicin/administration & dosage; Capsaicin/pharmacology; Cell Line; Curcumin/administration & dosage; Curcumin/pharmacology; Facial Pain/chemically induced; Facial Pain/physiopathology; Hot Temperature; Humans; Hyperalgesia/chemically induced; Hyperalgesia/physiopathology; Injections, Intraperitoneal; Injections, Subcutaneous; Kidney/cytology; Kidney/embryology; Male; Nose; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; TRPV Cation Channels/antagonists & inhibitors; Trigeminal Ganglion/cytology; Trigeminal Ganglion/drug effects

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Facial Pain / Nociceptors / Curcumin / TRPV Cation Channels / Hyperalgesia Language: En Journal: J Dent Res Year: 2010 Type: Article

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