Portuguese winemaking residues as a potential source of natural anti-adenoviral agents.
Int J Food Sci Nutr
; 61(4): 357-68, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20109126
ABSTRACT
To date there are no licensed systemic or topical treatments in Europe or the USA for adenovirus infections. In the present paper, we evaluate the effect of a polyphenol-based grape extract (NE) obtained from Portuguese white-winemaking by-products, and Resveratrol in pure form, on adenovirus type 5 infection. For this purpose, recombinant adenovirus vectors (Ad-5) and a human-derived cell line (293) were used as models. The NE and Resveratrol at the used concentrations do not induce cell cytotoxicity or direct virucidal activity; however, they reduce 4.5 and 6.5 log (TCID(50)/ml) on total infectious Ad-5 production, respectively. The capacity of Ad-5 replication upon removal of NE and Resveratrol after 24 h post infection was also evaluated. In contrast to Resveratrol, the highest evaluated NE concentration inhibits irreversibly the Ad-5 replication. These results provide useful information for the use of NE and Resveratrol as potential sources of promising natural antiviral agents on Ad-5 infection.
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Antiviral Agents
/
Stilbenes
/
Wine
/
Plant Extracts
/
Adenoviridae
/
Adenovirus Infections, Human
/
Vitis
Country/Region as subject:
Europa
Language:
En
Journal:
Int J Food Sci Nutr
Year:
2010
Type:
Article
Affiliation country:
Portugal