A rapid interference between glucocorticoids and cAMP-activated signalling in hypothalamic neurones prevents binding of phosphorylated cAMP response element binding protein and glucocorticoid receptor at the CRE-Like and composite GRE sites of thyrotrophin-releasing hormone gene promoter.

Díaz-Gallardo, M Y; Cote-Vélez, A; Charli, J L; Joseph-Bravo, P

Díaz-Gallardo, M Y; Cote-Vélez, A; Charli, J L; Joseph-Bravo, P.

Affiliation

Díaz-Gallardo MY; Departamento de Genética y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, México.

J Neuroendocrinol ; 22(4): 282-93, 2010 Apr.

Article in En | MEDLINE | ID: mdl-20136691

Subject(s)

Cyclic AMP Response Element-Binding Protein/metabolism; Cyclic AMP/pharmacology; Glucocorticoids/pharmacology; Hypothalamus/drug effects; Neurons/drug effects; Receptors, Glucocorticoid/metabolism; Response Elements; Thyrotropin-Releasing Hormone/genetics; Animals; Cells, Cultured; Cyclic AMP/antagonists & inhibitors; Drug Antagonism; Female; Gene Expression Regulation/drug effects; Glucocorticoids/antagonists & inhibitors; Hypothalamus/metabolism; Neurons/metabolism; Phosphorylation; Pregnancy; Promoter Regions, Genetic/drug effects; Protein Binding/drug effects; Rats; Rats, Wistar; Response Elements/drug effects; Signal Transduction/drug effects; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Receptors, Glucocorticoid / Thyrotropin-Releasing Hormone / Cyclic AMP Response Element-Binding Protein / Cyclic AMP / Response Elements / Glucocorticoids / Hypothalamus / Neurons Type of study: Prognostic_studies Language: En Journal: J Neuroendocrinol Year: 2010 Type: Article

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