Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts.

Morán, M; Rivera, H; Sánchez-Aragó, M; Blázquez, A; Merinero, B; Ugalde, C; Arenas, J; Cuezva, J M; Martín, M A

Morán, M; Rivera, H; Sánchez-Aragó, M; Blázquez, A; Merinero, B; Ugalde, C; Arenas, J; Cuezva, J M; Martín, M A.

Affiliation

Morán M; Centro de Investigación, Hospital Universitario 12 de Octubre, Madrid, Spain.

Biochim Biophys Acta ; 1802(5): 443-53, 2010 May.

Article in En | MEDLINE | ID: mdl-20153825

Subject(s)

Electron Transport Complex I/metabolism; Energy Metabolism; Fibroblasts/enzymology; Mitochondria/metabolism; Mitochondrial Diseases/genetics; Mutation/genetics; NADH Dehydrogenase/genetics; Acidosis/genetics; Acidosis/metabolism; Acidosis/pathology; Adenosine Triphosphate/metabolism; Blotting, Western; Cells, Cultured; Epilepsy/genetics; Epilepsy/metabolism; Epilepsy/pathology; Flow Cytometry; Fluorescent Antibody Technique; Glycolysis; Humans; Infant; Leukoencephalopathies/genetics; Leukoencephalopathies/metabolism; Leukoencephalopathies/pathology; Male; Mitochondria/drug effects; Mitochondrial Diseases/metabolism; NADH Dehydrogenase/metabolism; Oxygen Consumption; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reactive Oxygen Species/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin/cytology; Skin/metabolism

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Mitochondrial Diseases / Electron Transport Complex I / Energy Metabolism / Fibroblasts / Mitochondria / Mutation / NADH Dehydrogenase Language: En Journal: Biochim Biophys Acta Year: 2010 Type: Article Affiliation country: Spain

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