Baicalin, a flavonoid from Scutellaria baicalensis Georgi, activates large-conductance Ca2+-activated K+ channels via cyclic nucleotide-dependent protein kinases in mesenteric artery.

Lin, Yi-Ling; Dai, Zen-Kong; Lin, Rong-Jyh; Chu, Koung-Shing; Chen, Ing-Jun; Wu, Jiunn-Ren; Wu, Bin-Nan

Lin, Yi-Ling; Dai, Zen-Kong; Lin, Rong-Jyh; Chu, Koung-Shing; Chen, Ing-Jun; Wu, Jiunn-Ren; Wu, Bin-Nan.

Affiliation

Lin YL; Department of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan.

Phytomedicine ; 17(10): 760-70, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20171070

Subject(s)

Cyclic AMP-Dependent Protein Kinases/metabolism; Cyclic AMP/metabolism; Cyclic GMP-Dependent Protein Kinases/metabolism; Cyclic GMP/metabolism; Flavonoids/pharmacology; Mesenteric Arteries/drug effects; Potassium Channels, Calcium-Activated/agonists; Scutellaria baicalensis/chemistry; Animals; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/physiology; Female; Flavonoids/isolation & purification; Mesenteric Arteries/enzymology; Mesenteric Arteries/metabolism; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley

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Full text: 1 Database: MEDLINE Main subject: Flavonoids / Cyclic GMP-Dependent Protein Kinases / Cyclic AMP-Dependent Protein Kinases / Cyclic AMP / Cyclic GMP / Potassium Channels, Calcium-Activated / Scutellaria baicalensis / Mesenteric Arteries Language: En Journal: Phytomedicine Year: 2010 Type: Article Affiliation country: Taiwan

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