Low-molecular-mass peptides from the venom of the Amazonian viper Bothrops atrox protect against brain mitochondrial swelling in rat: potential for neuroprotection.

Martins, N M; Ferreira, D A S; Carvalho Rodrigues, M A; Cintra, A C O; Santos, N A G; Sampaio, S V; Santos, A C

Martins, N M; Ferreira, D A S; Carvalho Rodrigues, M A; Cintra, A C O; Santos, N A G; Sampaio, S V; Santos, A C.

Affiliation

Martins NM; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Av. do Café s/n, 14040-903 Ribeirão Preto SP, Brazil.

Toxicon ; 56(1): 86-92, 2010 Aug 01.

Article in En | MEDLINE | ID: mdl-20338188

Subject(s)

Bothrops; Crotalid Venoms/chemistry; Mitochondrial Swelling/drug effects; Neuroprotective Agents/therapeutic use; Peptides/therapeutic use; Reptilian Proteins/therapeutic use; Animals; Brain; Brazil; Drug Evaluation, Preclinical; Hydrogen Peroxide/metabolism; Male; Membrane Potential, Mitochondrial/drug effects; Mitochondria/drug effects; Molecular Weight; Neurodegenerative Diseases/drug therapy; Neuroprotective Agents/adverse effects; Neuroprotective Agents/chemistry; Neuroprotective Agents/isolation & purification; Oxidative Phosphorylation/drug effects; Peptides/adverse effects; Peptides/chemistry; Peptides/isolation & purification; Permeability/drug effects; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism; Reptilian Proteins/adverse effects; Reptilian Proteins/chemistry; Reptilian Proteins/isolation & purification

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Full text: 1 Database: MEDLINE Main subject: Peptides / Bothrops / Neuroprotective Agents / Crotalid Venoms / Reptilian Proteins / Mitochondrial Swelling Country/Region as subject: America do sul / Brasil Language: En Journal: Toxicon Year: 2010 Type: Article Affiliation country: Brazil

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