Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.

Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Lopez Cara, Carlota; Carrion, Maria Dora; Balzarini, Jan; Hamel, Ernest; Basso, Giuseppe; Bortolozzi, Roberta; Viola, Giampietro

Romagnoli, Romeo; Baraldi, Pier Giovanni; Cruz-Lopez, Olga; Lopez Cara, Carlota; Carrion, Maria Dora; Balzarini, Jan; Hamel, Ernest; Basso, Giuseppe; Bortolozzi, Roberta; Viola, Giampietro.

Affiliation

Romagnoli R; Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy. rmr@unife.it

Bioorg Med Chem Lett ; 20(9): 2733-9, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20378350

Subject(s)

Antineoplastic Agents/chemical synthesis; Chalcones/chemistry; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Caspase 3/metabolism; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Mice

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Full text: 1 Database: MEDLINE Main subject: Chalcones / Antineoplastic Agents Language: En Journal: Bioorg Med Chem Lett Year: 2010 Type: Article Affiliation country: Italy

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