Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes.
Anim Reprod Sci
; 120(1-4): 105-11, 2010 Jul.
Article
in En
| MEDLINE
| ID: mdl-20427135
ABSTRACT
An immune/inflammatory challenge can affect reproduction at the level of the hypothalamus, pituitary gland, or gonads. Nonetheless, the major impact is thought to occur within the brain or the pituitary gland. The present study was designed to examine the effect of intravenous (i.v.) lipopolysaccharide (LPS) injection on the expression of gonadotropin-releasing hormone (GnRH) and the gonadotropin-releasing hormone receptor (GnRHR) genes in the hypothalamic structures where GnRH neurons are located as well as in the anterior pituitary gland (AP) of anestrous ewes. We also determined the effect of LPS on luteinizing hormone (LH) release. It was found that i.v. LPS injection significantly decreased GnRH and GnRHR mRNAs levels in the preoptic area (40%, p
Full text:
1
Database:
MEDLINE
Main subject:
Pituitary Gland, Anterior
/
Anestrus
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Sheep
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Gonadotropin-Releasing Hormone
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Receptors, LHRH
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Endotoxins
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Hypothalamus
Language:
En
Journal:
Anim Reprod Sci
Year:
2010
Type:
Article
Affiliation country:
Poland