MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis.

Zhang, Z Y; Zhang, Z; Schluesener, H J

Zhang, Z Y; Zhang, Z; Schluesener, H J.

Affiliation

Zhang ZY; Institute of Brain Research, University of Tuebingen, Calwer Street 3, D-72076 Tuebingen, Baden-Württemberg, Germany. zhangzhiren@yahoo.com

Neuroscience ; 169(1): 370-7, 2010 Aug 11.

Article in En | MEDLINE | ID: mdl-20451583

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Benzamides/therapeutic use; Histone Deacetylase Inhibitors/therapeutic use; Neuritis, Autoimmune, Experimental/drug therapy; Pyridines/therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Benzamides/pharmacology; Cytokines/biosynthesis; Cytokines/genetics; Demyelinating Diseases/pathology; Drug Evaluation, Preclinical; Forkhead Transcription Factors/analysis; Gene Expression Regulation/drug effects; Histone Deacetylase Inhibitors/pharmacology; Inflammation; Lymph Nodes/metabolism; Lymph Nodes/pathology; Lymphocyte Subsets/pathology; Macrophages/pathology; Male; Matrix Metalloproteinase 9/biosynthesis; Matrix Metalloproteinase 9/genetics; Neuritis, Autoimmune, Experimental/enzymology; Neuritis, Autoimmune, Experimental/pathology; Nitric Oxide Synthase Type II/biosynthesis; Nitric Oxide Synthase Type II/genetics; Pyridines/pharmacology; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Rats; Rats, Inbred Lew; Sciatic Nerve/metabolism; Sciatic Nerve/pathology

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Full text: 1 Database: MEDLINE Main subject: Pyridines / Benzamides / Anti-Inflammatory Agents, Non-Steroidal / Histone Deacetylase Inhibitors / Neuritis, Autoimmune, Experimental Type of study: Prognostic_studies Language: En Journal: Neuroscience Year: 2010 Type: Article Affiliation country: Germany

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