Exposure to pyrithiamine increases ß-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain.

Zhao, Jing; Sun, Xiaojing; Yu, Zhe; Pan, Xiaoli; Gu, Fenghua; Chen, Jia; Dong, Wenxin; Zhao, Lei; Zhong, Chunjiu

Zhao, Jing; Sun, Xiaojing; Yu, Zhe; Pan, Xiaoli; Gu, Fenghua; Chen, Jia; Dong, Wenxin; Zhao, Lei; Zhong, Chunjiu.

Affiliation

Zhao J; Department of Neurology, Zhongshan Hospital & Shanghai Medical College, Fudan University, Shanghai 200032, China.

Neurotox Res ; 19(4): 575-83, 2011 May.

Article in En | MEDLINE | ID: mdl-20567953

Subject(s)

Amyloid beta-Peptides/metabolism; Brain/metabolism; Glycogen Synthase Kinase 3/metabolism; Pyrithiamine/toxicity; tau Proteins/metabolism; Animals; Brain/drug effects; Brain/enzymology; Enzyme Activation/drug effects; Enzyme Activation/physiology; Glycogen Synthase Kinase 3 beta; Male; Maze Learning/drug effects; Maze Learning/physiology; Mice; Mice, Transgenic; Phosphorylation/drug effects; Phosphorylation/physiology; Random Allocation

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Full text: 1 Database: MEDLINE Main subject: Pyrithiamine / Brain / Amyloid beta-Peptides / Tau Proteins / Glycogen Synthase Kinase 3 Language: En Journal: Neurotox Res Year: 2011 Type: Article Affiliation country: China

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