A superior semicircular canal dehiscence-induced air-bone gap in chinchilla.
Hear Res
; 269(1-2): 70-80, 2010 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-20638462
ABSTRACT
An SCD is a pathologic hole (or dehiscence) in the bone separating the superior semicircular canal from the cranial cavity that has been associated with a conductive hearing loss in patients with SCD syndrome. The conductive loss is defined by an audiometrically determined air-bone gap that results from the combination of a decrease in sensitivity to air-conducted sound and an increase in sensitivity to bone-conducted sound. Our goal is to demonstrate, through physiological measurements in an animal model, that mechanically altering the superior semicircular canal (SC) by introducing a hole (dehiscence) is sufficient to cause such an air-bone gap. We surgically introduced holes into the SC of chinchilla ears and evaluated auditory sensitivity (cochlear potential) in response to both air- and bone-conducted stimuli. The introduction of the SC hole led to a low-frequency (<2000 Hz) decrease in sensitivity to air-conducted stimuli and a low-frequency (<1000 Hz) increase in sensitivity to bone-conducted stimuli resulting in an air-bone gap. This result was consistent and reversible. The air-bone gaps in the animal results are qualitatively consistent with findings in patients with SCD syndrome.
Full text:
1
Database:
MEDLINE
Main subject:
Bone Conduction
/
Chinchilla
/
Semicircular Canals
/
Hearing Loss, Conductive
Type of study:
Prognostic_studies
Language:
En
Journal:
Hear Res
Year:
2010
Type:
Article
Affiliation country:
United States