Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.

Dikalova, Anna E; Góngora, María Carolina; Harrison, David G; Lambeth, J David; Dikalov, Sergey; Griendling, Kathy K

Dikalova, Anna E; Góngora, María Carolina; Harrison, David G; Lambeth, J David; Dikalov, Sergey; Griendling, Kathy K.

Affiliation

Dikalova AE; Department of Medicine, Emory University, Atlanta, Georgia 30322, USA.

Am J Physiol Heart Circ Physiol ; 299(3): H673-9, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20639222

Subject(s)

Endothelium, Vascular/metabolism; Muscle, Smooth, Vascular/metabolism; NADH, NADPH Oxidoreductases/metabolism; Nitric Oxide Synthase Type III/metabolism; Up-Regulation; Vasodilation/physiology; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Endothelium, Vascular/drug effects; Endothelium, Vascular/physiopathology; Hydrogen Peroxide/metabolism; Hypertension/chemically induced; Hypertension/metabolism; Hypertension/physiopathology; Mice; Mice, Transgenic; Muscle, Smooth, Vascular/drug effects; Muscle, Smooth, Vascular/physiopathology; NADH, NADPH Oxidoreductases/genetics; NADPH Oxidase 1; NG-Nitroarginine Methyl Ester/pharmacology; Nitric Oxide/metabolism; Polymerase Chain Reaction; Vasodilation/drug effects

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Full text: 1 Database: MEDLINE Main subject: Vasodilation / Endothelium, Vascular / Up-Regulation / Nitric Oxide Synthase Type III / Muscle, Smooth, Vascular / NADH, NADPH Oxidoreductases Language: En Journal: Am J Physiol Heart Circ Physiol Year: 2010 Type: Article Affiliation country: United States

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