Discovery of a novel Hsp90 inhibitor by fragment linking.

Barker, John J; Barker, Oliver; Courtney, Stephen M; Gardiner, Mihaly; Hesterkamp, Thomas; Ichihara, Osamu; Mather, Owen; Montalbetti, Christian A G N; Müller, Annett; Varasi, Mario; Whittaker, Mark; Yarnold, Christopher J

Barker, John J; Barker, Oliver; Courtney, Stephen M; Gardiner, Mihaly; Hesterkamp, Thomas; Ichihara, Osamu; Mather, Owen; Montalbetti, Christian A G N; Müller, Annett; Varasi, Mario; Whittaker, Mark; Yarnold, Christopher J.

Affiliation

Barker JJ; Evotec, Abingdon, Oxfordshire, OX14 4SA, UK.

ChemMedChem ; 5(10): 1697-700, 2010 Oct 04.

Article in En | MEDLINE | ID: mdl-20665758

Subject(s)

Adenine/analogs & derivatives; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Pyrazoles/chemistry; Adenine/chemical synthesis; Adenine/chemistry; Adenine/pharmacology; Binding Sites; Computer Simulation; Drug Evaluation, Preclinical; HSP90 Heat-Shock Proteins/metabolism; Pyrazoles/chemical synthesis; Pyrazoles/pharmacology; Thermodynamics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Adenine / HSP90 Heat-Shock Proteins Language: En Journal: ChemMedChem Year: 2010 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Adenine / HSP90 Heat-Shock Proteins Language: En Journal: ChemMedChem Year: 2010 Type: Article