Development of a simple system for screening anti-hepatitis C virus drugs utilizing mutants capable of vigorous replication.

Yu, Lijuan; Aoki, Chie; Shimizu, Yohko; Shimizu, Kazufumi; Hou, Wei; Yagyu, Fumihiro; Wen, Xianzi; Oshima, Masamichi; Iwamoto, Aikichi; Gao, Bin; Liu, Wenjun; Gao, George Fu; Kitamura, Yoshihiro

Yu, Lijuan; Aoki, Chie; Shimizu, Yohko; Shimizu, Kazufumi; Hou, Wei; Yagyu, Fumihiro; Wen, Xianzi; Oshima, Masamichi; Iwamoto, Aikichi; Gao, Bin; Liu, Wenjun; Gao, George Fu; Kitamura, Yoshihiro.

Affiliation

Yu L; China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.

J Virol Methods ; 169(2): 380-4, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20713089

Subject(s)

Antiviral Agents/pharmacology; Drug Evaluation, Preclinical/methods; Hepacivirus/drug effects; Hepacivirus/physiology; Virus Replication/drug effects; Adaptation, Biological; Cell Line; Genes, Reporter; Hepatocytes/virology; Humans; Interferon-alpha/pharmacology; Luciferases, Renilla/genetics; Luciferases, Renilla/metabolism; Microbial Sensitivity Tests/methods; RNA, Viral/genetics; Sequence Analysis, DNA; Serial Passage; Staining and Labeling/methods; Virus Cultivation/methods

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Virus Replication / Hepacivirus / Drug Evaluation, Preclinical Type of study: Diagnostic_studies / Screening_studies Language: En Journal: J Virol Methods Year: 2010 Type: Article Affiliation country: China

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