Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen, Liye; Zeng, Xin; Wang, Jihui; Briggs, Simon S; O'Neill, Eric; Li, Jiliang; Leek, Russell; Kerr, David J; Harris, Adrian L; Cai, Shijie

Chen, Liye; Zeng, Xin; Wang, Jihui; Briggs, Simon S; O'Neill, Eric; Li, Jiliang; Leek, Russell; Kerr, David J; Harris, Adrian L; Cai, Shijie.

Affiliation

Chen L; Department of Clinical Pharmacology, University of Oxford, John Radcliffe Hospital, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK.

Am J Pathol ; 177(5): 2671-80, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20847284

Subject(s)

Biopterins/analogs & derivatives; Neovascularization, Pathologic; Nitric Oxide Synthase Type III/metabolism; Signal Transduction/physiology; Animals; Biopterins/metabolism; COS Cells; Cell Movement; Cell Proliferation; Chlorocebus aethiops; Enzyme Activation; Humans; Mice; NIH 3T3 Cells; Nitric Oxide/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Pterins/metabolism; Tumor Microenvironment; ras Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Biopterins / Signal Transduction / Nitric Oxide Synthase Type III / Neovascularization, Pathologic Language: En Journal: Am J Pathol Year: 2010 Type: Article Affiliation country: United kingdom

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