Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog Î³-tocotrienol: evidence of a role for tetrahydrobiopterin.

Berbee, Maaike; Fu, Qiang; Boerma, Marjan; Pathak, Rupak; Zhou, Daohong; Kumar, K Sree; Hauer-Jensen, Martin

Berbee, Maaike; Fu, Qiang; Boerma, Marjan; Pathak, Rupak; Zhou, Daohong; Kumar, K Sree; Hauer-Jensen, Martin.

Affiliation

Berbee M; University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Int J Radiat Oncol Biol Phys ; 79(3): 884-91, 2011 Mar 01.

Article in En | MEDLINE | ID: mdl-20950957

Subject(s)

Biopterins/analogs & derivatives; Chromans/pharmacology; Intracellular Signaling Peptides and Proteins/metabolism; Vitamin E/analogs & derivatives; Animals; Apoptosis/drug effects; Biological Availability; Biopterins/analysis; Biopterins/metabolism; Biopterins/pharmacology; Bone Marrow Cells; Colony-Forming Units Assay; Endothelial Cells/drug effects; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; GTP Cyclohydrolase/metabolism; Intracellular Signaling Peptides and Proteins/genetics; Lung/metabolism; Male; Mice; Nitric Oxide Synthase/metabolism; Oxidative Stress/drug effects; Peroxynitrous Acid/biosynthesis; Protein Binding; Radiation Dosage; Random Allocation; Transcription, Genetic/drug effects; Vitamin E/pharmacology; Whole-Body Irradiation

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Full text: 1 Database: MEDLINE Main subject: Vitamin E / Biopterins / Chromans / Intracellular Signaling Peptides and Proteins Language: En Journal: Int J Radiat Oncol Biol Phys Year: 2011 Type: Article Affiliation country: United States

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