Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong.

Wang, Yi-Han; Liang, Shuang; Xu, De-Sheng; Lin, Xiao; He, Chun-Yong; Feng, Yi; Hong, Yan-Long

Wang, Yi-Han; Liang, Shuang; Xu, De-Sheng; Lin, Xiao; He, Chun-Yong; Feng, Yi; Hong, Yan-Long.

Affiliation

Wang YH; Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, China.

J Pharm Pharmacol ; 63(2): 261-6, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21235591

Subject(s)

Analgesics/pharmacology; Benzofurans/pharmacology; Brain/drug effects; Brain/metabolism; Drugs, Chinese Herbal/pharmacology; Migraine Disorders/drug therapy; 5-Hydroxytryptophan/blood; 5-Hydroxytryptophan/metabolism; Acetates; Animals; Benzofurans/isolation & purification; Dopamine/blood; Dopamine/metabolism; Drugs, Chinese Herbal/chemistry; Drugs, Chinese Herbal/isolation & purification; Hydroxyindoleacetic Acid/blood; Hydroxyindoleacetic Acid/metabolism; Ligusticum; Mice; Migraine Disorders/chemically induced; Migraine Disorders/metabolism; Neurotransmitter Agents/blood; Neurotransmitter Agents/metabolism; Nitric Oxide/blood; Nitric Oxide/metabolism; Nitroglycerin/pharmacology; Norepinephrine/blood; Norepinephrine/metabolism; Pain Threshold/drug effects; Rats; Rats, Sprague-Dawley; Serotonin/blood; Serotonin/metabolism

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Benzofurans / Brain / Drugs, Chinese Herbal / Analgesics / Migraine Disorders Language: En Journal: J Pharm Pharmacol Year: 2011 Type: Article Affiliation country: China

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