Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation.

Kwakye, Gunnar F; Li, Daphne; Bowman, Aaron B

Kwakye, Gunnar F; Li, Daphne; Bowman, Aaron B.

Affiliation

Kwakye GF; Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN 37232-8552, USA.

Neurotoxicology ; 32(5): 630-9, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21238486

Subject(s)

Corpus Striatum/metabolism; Fura-2/metabolism; High-Throughput Screening Assays/methods; Huntington Disease/metabolism; Manganese/deficiency; Manganese/metabolism; Animals; Cell Line; Corpus Striatum/pathology; Huntington Disease/genetics; Mice; Mice, Mutant Strains; Mutation/genetics

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Full text: 1 Database: MEDLINE Main subject: Fura-2 / Huntington Disease / Corpus Striatum / High-Throughput Screening Assays / Manganese Language: En Journal: Neurotoxicology Year: 2011 Type: Article Affiliation country: United States

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