Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells.

Zhou, Rongping; Zhang, Zhongmin; Zhao, Li; Jia, Chunhong; Xu, Song; Mai, Qiguang; Lu, Ming; Huang, Mingjun; Wang, Liang; Wang, Xiaokai; Jin, Dadi; Bai, Xiaochun

Zhou, Rongping; Zhang, Zhongmin; Zhao, Li; Jia, Chunhong; Xu, Song; Mai, Qiguang; Lu, Ming; Huang, Mingjun; Wang, Liang; Wang, Xiaokai; Jin, Dadi; Bai, Xiaochun.

Affiliation

Zhou R; Research Institute of Orthopedic, Southern Medical University, Guangzhou 510630, China.

J Orthop Res ; 29(6): 846-52, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21246613

Subject(s)

Bone Neoplasms/drug therapy; Drugs, Chinese Herbal/therapeutic use; Oleanolic Acid/therapeutic use; Osteosarcoma/drug therapy; TOR Serine-Threonine Kinases/antagonists & inhibitors; Apoptosis/drug effects; Bone Neoplasms/metabolism; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal/pharmacology; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Oleanolic Acid/pharmacology; Osteosarcoma/metabolism; Proteins/antagonists & inhibitors; Proteins/metabolism; TOR Serine-Threonine Kinases/metabolism; Transcription Factors/antagonists & inhibitors; Transcription Factors/metabolism

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Oleanolic Acid / Bone Neoplasms / Drugs, Chinese Herbal / Osteosarcoma / TOR Serine-Threonine Kinases Language: En Journal: J Orthop Res Year: 2011 Type: Article Affiliation country: China

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