Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret, Marc; Smith, Mark A; Knauf, Claude; Al-Qassab, Hind; Woods, Angela; Heslegrave, Amanda; Piipari, Kaisa; Emmanuel, Julian J; Colom, André; Valet, Philippe; Cani, Patrice D; Begum, Ghazala; White, Anne; Mucket, Phillip; Peters, Marco; Mizuno, Keiko; Batterham, Rachel L; Giese, K Peter; Ashworth, Alan; Burcelin, Remy; Ashford, Michael L; Carling, David; Withers, Dominic J

Claret, Marc; Smith, Mark A; Knauf, Claude; Al-Qassab, Hind; Woods, Angela; Heslegrave, Amanda; Piipari, Kaisa; Emmanuel, Julian J; Colom, André; Valet, Philippe; Cani, Patrice D; Begum, Ghazala; White, Anne; Mucket, Phillip; Peters, Marco; Mizuno, Keiko; Batterham, Rachel L; Giese, K Peter; Ashworth, Alan; Burcelin, Remy; Ashford, Michael L; Carling, David; Withers, Dominic J.

Affiliation

Claret M; Laboratory of Diabetes and Obesity, Endocrinology and Nutrition Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic de Barcelona, Barcelona, Spain.

Diabetes ; 60(3): 735-45, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21266325

Subject(s)

Glucose/metabolism; Homeostasis/genetics; Hypothalamus/metabolism; Neurons/metabolism; Pro-Opiomelanocortin/metabolism; Protein Serine-Threonine Kinases/metabolism; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Area Under Curve; Body Weight/genetics; Cell Count; Eating/genetics; Electrophysiology; Energy Metabolism/genetics; Female; Glucose/genetics; Glucose Clamp Technique; Immunohistochemistry; Insulin Resistance/genetics; Male; Mice; Mice, Transgenic; Pro-Opiomelanocortin/genetics; Protein Serine-Threonine Kinases/genetics; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/genetics; Statistics, Nonparametric

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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Pro-Opiomelanocortin / Protein Serine-Threonine Kinases / Glucose / Homeostasis / Hypothalamus / Neurons Type of study: Prognostic_studies Language: En Journal: Diabetes Year: 2011 Type: Article Affiliation country: Spain

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