Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.

Kang, B H; Tavecchio, M; Goel, H L; Hsieh, C-C; Garlick, D S; Raskett, C M; Lian, J B; Stein, G S; Languino, L R; Altieri, D C

Kang, B H; Tavecchio, M; Goel, H L; Hsieh, C-C; Garlick, D S; Raskett, C M; Lian, J B; Stein, G S; Languino, L R; Altieri, D C.

Affiliation

Kang BH; Prostate Cancer Discovery and Development Program, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Br J Cancer ; 104(4): 629-34, 2011 Feb 15.

Article in En | MEDLINE | ID: mdl-21285984

Subject(s)

Adenocarcinoma/prevention & control; Antineoplastic Agents/therapeutic use; Cell Proliferation/drug effects; Guanidines/therapeutic use; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Lactams, Macrocyclic/therapeutic use; Prostatic Neoplasms/prevention & control; Adenocarcinoma/genetics; Adenocarcinoma/pathology; Animals; Antineoplastic Agents/pharmacology; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Female; Genetic Predisposition to Disease; Guanidines/pharmacology; HSP90 Heat-Shock Proteins/metabolism; Lactams, Macrocyclic/pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria/drug effects; Mitochondria/metabolism; Molecular Targeted Therapy/methods; Neoplasm Metastasis; Prostatic Intraepithelial Neoplasia/genetics; Prostatic Intraepithelial Neoplasia/pathology; Prostatic Intraepithelial Neoplasia/prevention & control; Prostatic Neoplasms/genetics; Prostatic Neoplasms/pathology

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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Adenocarcinoma / HSP90 Heat-Shock Proteins / Lactams, Macrocyclic / Cell Proliferation / Guanidines / Antineoplastic Agents Language: En Journal: Br J Cancer Year: 2011 Type: Article Affiliation country: United States

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