Ent-16ß,17-dihydroxy-kauran-19-oic acid, a kaurane diterpene acid from Siegesbeckia pubescens, presents antiplatelet and antithrombotic effects in rats.

Wang, J P; Xu, H X; Wu, Y X; Ye, Y J; Ruan, J L; Xiong, C M; Cai, Y L

Wang, J P; Xu, H X; Wu, Y X; Ye, Y J; Ruan, J L; Xiong, C M; Cai, Y L.

Affiliation

Wang JP; Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation of Hubei Province, College of Pharmacy, Huazhong University of Science and Technology, 13# Hangkong Road, Wuhan 430030, PR China.

Phytomedicine ; 18(10): 873-8, 2011 Jul 15.

Article in En | MEDLINE | ID: mdl-21377851

Subject(s)

Asteraceae/chemistry; Diterpenes, Kaurane/pharmacology; Fibrinolytic Agents/pharmacology; Platelet Aggregation Inhibitors/pharmacology; Platelet Aggregation; 6-Ketoprostaglandin F1 alpha/blood; Adenosine Diphosphate/metabolism; Animals; Coronary Thrombosis/drug therapy; Cyclic AMP/blood; Diterpenes, Kaurane/administration & dosage; Epoprostenol/blood; Female; Fibrinolytic Agents/toxicity; Hemorrhage/chemically induced; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Platelet Aggregation Inhibitors/toxicity; Rats; Rats, Wistar; Thrombin/pharmacology; Thromboxane A2/blood; Thyroglobulin/blood

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Full text: 1 Database: MEDLINE Main subject: Platelet Aggregation Inhibitors / Platelet Aggregation / Asteraceae / Diterpenes, Kaurane / Fibrinolytic Agents Type of study: Prognostic_studies Language: En Journal: Phytomedicine Year: 2011 Type: Article

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