Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.

Gangadharan, Vijayan; Wang, Rui; Ulzhöfer, Bettina; Luo, Ceng; Bardoni, Rita; Bali, Kiran Kumar; Agarwal, Nitin; Tegeder, Irmgard; Hildebrandt, Ullrich; Nagy, Gergely G; Todd, Andrew J; Ghirri, Alessia; Häussler, Annette; Sprengel, Rolf; Seeburg, Peter H; MacDermott, Amy B; Lewin, Gary R; Kuner, Rohini

Gangadharan, Vijayan; Wang, Rui; Ulzhöfer, Bettina; Luo, Ceng; Bardoni, Rita; Bali, Kiran Kumar; Agarwal, Nitin; Tegeder, Irmgard; Hildebrandt, Ullrich; Nagy, Gergely G; Todd, Andrew J; Ghirri, Alessia; Häussler, Annette; Sprengel, Rolf; Seeburg, Peter H; MacDermott, Amy B; Lewin, Gary R; Kuner, Rohini.

Affiliation

Gangadharan V; Institute for Pharmacology, Heidelberg University, Heidelberg, Germany.

J Clin Invest ; 121(4): 1608-23, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21383497

Subject(s)

Inflammation/physiopathology; Nociceptors/physiology; Pain/physiopathology; Receptors, AMPA/physiology; Afferent Pathways/growth & development; Afferent Pathways/physiopathology; Animals; Arthritis, Experimental/physiopathology; Benzodiazepines/pharmacology; Calcium/metabolism; Ganglia, Spinal/growth & development; Ganglia, Spinal/physiopathology; Inflammation/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain/drug therapy; Permeability; Receptors, AMPA/antagonists & inhibitors; Receptors, AMPA/deficiency; Receptors, AMPA/genetics; Synaptic Transmission

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Full text: 1 Database: MEDLINE Main subject: Pain / Nociceptors / Receptors, AMPA / Inflammation Type of study: Prognostic_studies Language: En Journal: J Clin Invest Year: 2011 Type: Article Affiliation country: Germany

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