Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection.

Gastaminza, Pablo; Pitram, Suresh M; Dreux, Marlene; Krasnova, Larissa B; Whitten-Bauer, Christina; Dong, Jiajia; Chung, Josan; Fokin, Valery V; Sharpless, K Barry; Chisari, Francis V

Gastaminza, Pablo; Pitram, Suresh M; Dreux, Marlene; Krasnova, Larissa B; Whitten-Bauer, Christina; Dong, Jiajia; Chung, Josan; Fokin, Valery V; Sharpless, K Barry; Chisari, Francis V.

Affiliation

Gastaminza P; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 9203, USA. pgastaminza@cnb.csic.es

J Virol ; 85(11): 5513-23, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21430055

Subject(s)

Antiviral Agents/pharmacology; Diamines/pharmacology; Hepacivirus/drug effects; Stilbenes/pharmacology; Virus Replication/drug effects; Antiviral Agents/chemistry; Antiviral Agents/isolation & purification; Antiviral Agents/toxicity; Cell Line; Cell Survival/drug effects; Diamines/chemistry; Diamines/isolation & purification; Diamines/toxicity; Drug Evaluation, Preclinical/methods; Drug Resistance, Viral; Hepatocytes/drug effects; Hepatocytes/virology; Humans; Microbial Sensitivity Tests; RNA, Viral/metabolism; Stilbenes/chemistry; Stilbenes/isolation & purification; Stilbenes/toxicity; Structure-Activity Relationship; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/metabolism

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Stilbenes / Virus Replication / Hepacivirus / Diamines Language: En Journal: J Virol Year: 2011 Type: Article Affiliation country: United States

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