Triptolide inhibits IFN-Î³ signaling via the Jak/STAT pathway in HaCaT keratinocytes.

Hongqin, Tu; Xinyu, Li; Heng, Gu; Lanfang, Xu; Yongfang, Wang; Shasha, Song

Hongqin, Tu; Xinyu, Li; Heng, Gu; Lanfang, Xu; Yongfang, Wang; Shasha, Song.

Affiliation

Hongqin T; Department of Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Phytother Res ; 25(11): 1678-85, 2011 Nov.

Article in En | MEDLINE | ID: mdl-21433155

Subject(s)

Diterpenes/pharmacology; Interferon-gamma/metabolism; Keratinocytes/drug effects; Phenanthrenes/pharmacology; Signal Transduction/drug effects; Cell Line; Cell Survival; Epoxy Compounds/pharmacology; Humans; Intercellular Adhesion Molecule-1/metabolism; Janus Kinase 2/metabolism; Keratinocytes/metabolism; Phosphorylation; Receptors, Interferon/metabolism; STAT1 Transcription Factor/metabolism; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins/metabolism; Tripterygium/chemistry; Interferon gamma Receptor

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Full text: 1 Database: MEDLINE Main subject: Phenanthrenes / Signal Transduction / Keratinocytes / Interferon-gamma / Diterpenes Language: En Journal: Phytother Res Year: 2011 Type: Article Affiliation country: China

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