Early effects of oral administration of lafutidine with peppermint oil, compared with lafutidine alone, on intragastric pH values.
Hepatogastroenterology
; 58(105): 235-8, 2011.
Article
in En
| MEDLINE
| ID: mdl-21510321
ABSTRACT
BACKGROUND/AIMS:
Ideally, medications for the treatment of acid-related diseases should have a rapid onset of action to promote hemostasis and the resolution of symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of lafutidine alone or combined with peppermint oil.METHODOLOGY:
Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 4 hours after a single oral administration of lafutidine (10 mg) or the administration of lafutidine (10 mg) with peppermint oil (0.64 mL). Each administration was separated by a 7-day washout period.RESULTS:
No significant difference in the average pH was observed during the 4-hour period after the combined administration of lafutidine and peppermint oil and after the administration of lafutidine alone (median gastric pH 5.09 versus 5.29; p = 0.3122).CONCLUSIONS:
In H. pylori-negative healthy male subjects, an oral dose of lafutidine combined with peppermint oil did not increase the intragastric pH faster than lafutidine alone.
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Database:
MEDLINE
Main subject:
Piperidines
/
Pyridines
/
Plant Oils
/
Gastric Acidity Determination
/
Acetamides
/
Anti-Ulcer Agents
Type of study:
Clinical_trials
Language:
En
Journal:
Hepatogastroenterology
Year:
2011
Type:
Article
Affiliation country:
Japan