Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.
Blood
; 118(2): 330-8, 2011 Jul 14.
Article
in En
| MEDLINE
| ID: mdl-21551236
ABSTRACT
Human mesenchymal stem/progenitor cells (hMSCs) repair tissues and modulate immune systems but the mechanisms are not fully understood. We demonstrated that hMSCs are activated by inflammatory signals to secrete the anti-inflammatory protein, TNF-α-stimulated gene 6 protein (TSG-6) and thereby create a negative feedback loop that reduces inflammation in zymosan-induced peritonitis. The results demonstrate for the first time that TSG-6 interacts through the CD44 receptor on resident macrophages to decrease zymosan/TLR2-mediated nuclear translocation of the NF-κB. The negative feedback loop created by MSCs through TSG-6 attenuates the inflammatory cascade that is initiated by resident macrophages and then amplified by mesothelial cells and probably other cells of the peritoneum. Because inflammation underlies many pathologic processes, including immune responses, the results may explain the beneficial effects of MSCs and TSG-6 in several disease models.
Full text:
1
Database:
MEDLINE
Main subject:
Peritonitis
/
Cell Adhesion Molecules
/
NF-kappa B
/
Macrophages, Peritoneal
/
Toll-Like Receptor 2
/
Mesenchymal Stem Cells
Type of study:
Prognostic_studies
Language:
En
Journal:
Blood
Year:
2011
Type:
Article
Affiliation country:
United States