TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases.
Int Immunopharmacol
; 11(10): 1451-6, 2011 Oct.
Article
in En
| MEDLINE
| ID: mdl-21586344
ABSTRACT
Toll-like receptors (TLRs) are generally involved in host immune responses against microbial invasions. Dysfunction of TLRs is closely related to infectious and inflammatory diseases, for which therapeutic manipulation with TLRs agonists and antagonists represent a promising drug strategy. Medicinal plants were used traditionally for the prevention and treatment of infectious and inflammatory diseases. Active compounds derived from these plants were also found with unique features as TLRs agonists and antagonists. These findings bring about new hopes for the application of these naturally existed TLRs modulators. They also provide evidences encouraging further research work of continued characterization for these compounds, which will become promising drug candidates in TLRs-based therapy in the future.
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Plantas_medicinales
Main subject:
Autoimmune Diseases
/
Plant Extracts
/
Toll-Like Receptors
/
Infections
/
Phytotherapy
Language:
En
Journal:
Int Immunopharmacol
Year:
2011
Type:
Article