AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation.

Jose, Caroline; Hébert-Chatelain, Etienne; Bellance, Nadège; Larendra, Anaïs; Su, Melser; Nouette-Gaulain, Karine; Rossignol, Rodrigue

Jose, Caroline; Hébert-Chatelain, Etienne; Bellance, Nadège; Larendra, Anaïs; Su, Melser; Nouette-Gaulain, Karine; Rossignol, Rodrigue.

Affiliation

Jose C; (MRGM) Maladies Rares: Génétique et Métabolisme, Université Victor Segalen, F-33076 Bordeaux, France.

Biochim Biophys Acta ; 1807(6): 707-18, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21692240

Subject(s)

Aminoimidazole Carboxamide/analogs & derivatives; Cell Proliferation/drug effects; Neoplasms/pathology; Oncogene Protein v-akt/metabolism; Oxidative Phosphorylation/drug effects; Oxidative Stress/drug effects; Ribonucleotides/pharmacology; Aminoimidazole Carboxamide/pharmacology; Drug Evaluation, Preclinical; Enzyme Activation/drug effects; HeLa Cells; Hep G2 Cells; Humans; Hypoglycemic Agents/pharmacology; Organ Specificity/drug effects; Time Factors; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Oxidative Phosphorylation / Ribonucleotides / Oxidative Stress / Cell Proliferation / Oncogene Protein v-akt / Aminoimidazole Carboxamide / Neoplasms Language: En Journal: Biochim Biophys Acta Year: 2011 Type: Article Affiliation country: France

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