Kirenol upregulates nuclear annexin-1 which interacts with NF-&#954;B to attenuate synovial inflammation of collagen-induced arthritis in rats.

Wang, Zhe-Ming; Zhu, Shi-Gong; Wu, Zai-Wang; Lu, Yue; Fu, Hong-Zheng; Qian, Rui-Qin

Kirenol upregulates nuclear annexin-1 which interacts with NF-κB to attenuate synovial inflammation of collagen-induced arthritis in rats.

Wang, Zhe-Ming; Zhu, Shi-Gong; Wu, Zai-Wang; Lu, Yue; Fu, Hong-Zheng; Qian, Rui-Qin.

Affiliation

Wang ZM; Department of Integrated Chinese Traditional with Western Medicine, Peking University Health Science Center, Beijing 100191, PR China. wangzheming@bjmu.edu.cn

J Ethnopharmacol ; 137(1): 774-82, 2011 Sep 01.

Article in En | MEDLINE | ID: mdl-21745559

Subject(s)

Annexin A1/metabolism; Anti-Inflammatory Agents/pharmacology; Arthritis, Experimental/drug therapy; Cell Nucleus/drug effects; Diterpenes/pharmacology; NF-kappa B/metabolism; Synovial Membrane/drug effects; Adrenocorticotropic Hormone/blood; Animals; Arthritis, Experimental/chemically induced; Arthritis, Experimental/immunology; Arthritis, Experimental/metabolism; Arthritis, Experimental/pathology; Binding Sites; Blotting, Western; Cell Nucleus/immunology; Cell Nucleus/metabolism; Collagen Type II; DNA/metabolism; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Inflammation Mediators/metabolism; Interleukin-1beta/metabolism; Male; Prednisolone/pharmacology; Rats; Rats, Wistar; Receptors, Glucocorticoid/metabolism; Synovial Membrane/immunology; Synovial Membrane/metabolism; Synovial Membrane/pathology; Time Factors; Up-Regulation

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Experimental / Synovial Membrane / Cell Nucleus / NF-kappa B / Annexin A1 / Diterpenes / Anti-Inflammatory Agents Language: En Journal: J Ethnopharmacol Year: 2011 Type: Article

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