Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.

Yeung, John H K; Or, Penelope M Y

Yeung, John H K; Or, Penelope M Y.

Affiliation

Yeung JH; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. johnyeung@cuhk.edu.hk

Phytomedicine ; 18(13): 1170-5, 2011 Oct 15.

Article in En | MEDLINE | ID: mdl-21757329

Subject(s)

Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Coriolaceae/chemistry; Cytochrome P-450 Enzyme Inhibitors; Microsomes, Liver/drug effects; Proteoglycans/pharmacology; Tolbutamide/metabolism; Animals; Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System/metabolism; Enzyme Inhibitors/pharmacology; Humans; Hydroxylation/drug effects; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Plant Extracts/pharmacology; Plants, Medicinal/chemistry; Proteoglycans/chemistry; Rats; Tolbutamide/pharmacology

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas Main subject: Proteoglycans / Tolbutamide / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Coriolaceae / Cytochrome P-450 Enzyme Inhibitors Language: En Journal: Phytomedicine Year: 2011 Type: Article Affiliation country: China

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