Honokiol attenuates vascular contraction through the inhibition of the RhoA/Rho-kinase signalling pathway in rat aortic rings.

Seok, Young Mi; Cho, Hae Joung; Cha, Byung-Yoon; Woo, Je-Tae; Kim, In Kyeom

Seok, Young Mi; Cho, Hae Joung; Cha, Byung-Yoon; Woo, Je-Tae; Kim, In Kyeom.

Affiliation

Seok YM; Cardiovascular Research Institute, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

J Pharm Pharmacol ; 63(9): 1244-51, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21827498

Subject(s)

Biphenyl Compounds/pharmacology; Lignans/pharmacology; Magnolia/chemistry; Muscle, Smooth, Vascular/drug effects; Plant Extracts/pharmacology; Vasoconstriction/drug effects; Vasodilator Agents/pharmacology; rho-Associated Kinases/antagonists & inhibitors; rhoA GTP-Binding Protein/antagonists & inhibitors; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta/drug effects; Dose-Response Relationship, Drug; Male; Muscle Contraction/drug effects; Muscle, Smooth, Vascular/metabolism; Muscle, Smooth, Vascular/physiology; Myosin Light Chains/metabolism; Myosin-Light-Chain Phosphatase/metabolism; Phosphorylation/drug effects; Pyridones; Rats; Rats, Sprague-Dawley; Signal Transduction/drug effects; Sodium Fluoride

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Full text: 1 Database: MEDLINE Main subject: Vasoconstriction / Vasodilator Agents / Biphenyl Compounds / Plant Extracts / Lignans / RhoA GTP-Binding Protein / Magnolia / Rho-Associated Kinases / Muscle, Smooth, Vascular Language: En Journal: J Pharm Pharmacol Year: 2011 Type: Article

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