Anti-Inflammatory Agents/pharmacology; Arthritis, Experimental/drug therapy; Hemin/pharmacology; Ibuprofen/pharmacology; Analgesics/administration & dosage; Analgesics/pharmacology; Analgesics/therapeutic use; Animals; Anti-Inflammatory Agents/administration & dosage; Anti-Inflammatory Agents/therapeutic use; Arthritis, Experimental/chemically induced; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Edema/chemically induced; Edema/drug therapy; Female; Freund's Adjuvant/toxicity; Hemin/administration & dosage; Hemin/therapeutic use; Hemin/toxicity; Hyperalgesia/drug therapy; Ibuprofen/administration & dosage; Ibuprofen/therapeutic use; Inflammation/chemically induced; Inflammation/drug therapy; Male; Pain Measurement; Random Allocation; Range of Motion, Articular; Rats; Rats, Wistar