Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands.

Teng, Heidi; Thakur, Ganesh A; Makriyannis, Alexandros

Teng, Heidi; Thakur, Ganesh A; Makriyannis, Alexandros.

Affiliation

Teng H; Center for Drug Discovery, 116 Mugar Life Sciences Building, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, United States.

Bioorg Med Chem Lett ; 21(19): 5999-6002, 2011 Oct 01.

Article in En | MEDLINE | ID: mdl-21880487

Subject(s)

Alkanesulfonates/metabolism; Analgesics/metabolism; Benzofurans/metabolism; Benzopyrans/metabolism; Drug Design; Nitriles/metabolism; Receptor, Cannabinoid, CB1/metabolism; Receptor, Cannabinoid, CB2/metabolism; Alkanesulfonates/chemistry; Alkanesulfonates/pharmacology; Analgesics/chemical synthesis; Analgesics/chemistry; Analgesics/pharmacology; Animals; Benzofurans/chemical synthesis; Benzofurans/chemistry; Benzofurans/pharmacology; Benzopyrans/chemical synthesis; Benzopyrans/chemistry; Benzopyrans/pharmacology; Chronic Pain/drug therapy; Chronic Pain/physiopathology; Computer Simulation; Drug Evaluation, Preclinical; Humans; Ligands; Mice; Molecular Conformation; Molecular Targeted Therapy; Neuralgia/drug therapy; Neuralgia/physiopathology; Nitriles/chemistry; Nitriles/pharmacology; Protein Binding; Radioligand Assay; Receptor, Cannabinoid, CB1/agonists; Receptor, Cannabinoid, CB2/agonists; Software; Structure-Activity Relationship; Substrate Specificity

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Full text: 1 Database: MEDLINE Main subject: Benzofurans / Benzopyrans / Drug Design / Alkanesulfonates / Receptor, Cannabinoid, CB1 / Receptor, Cannabinoid, CB2 / Analgesics / Nitriles Language: En Journal: Bioorg Med Chem Lett Year: 2011 Type: Article Affiliation country: United States

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