Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.

Tsai, Pei-Yi; Ka, Shuk-Man; Chang, Jia-Ming; Lai, Jenn-Haung; Dai, Ming-Shen; Jheng, Huei-Lin; Kuo, Mao-Tien; Chen, Peini; Chen, Ann

Tsai, Pei-Yi; Ka, Shuk-Man; Chang, Jia-Ming; Lai, Jenn-Haung; Dai, Ming-Shen; Jheng, Huei-Lin; Kuo, Mao-Tien; Chen, Peini; Chen, Ann.

Affiliation

Tsai PY; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, and Development Center for Biotechnology, Taipei, Taiwan, Republic of China.

Arthritis Rheum ; 64(1): 232-42, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21905011

Subject(s)

Interleukin-18/metabolism; Lupus Nephritis/drug therapy; NF-E2-Related Factor 2/biosynthesis; T-Lymphocytes/drug effects; Ubiquinone/analogs & derivatives; Animals; B-Lymphocytes/drug effects; B-Lymphocytes/immunology; Cell Proliferation/drug effects; Disease Models, Animal; Disease Progression; Drugs, Chinese Herbal/pharmacology; Immunoglobulin G/metabolism; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Lupus Nephritis/immunology; Lupus Nephritis/metabolism; Lymphocyte Activation/drug effects; Mice; Mice, Inbred NZB; Plant Extracts/pharmacology; T-Lymphocytes/immunology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/immunology; Ubiquinone/pharmacology

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Lupus Nephritis / T-Lymphocytes / Ubiquinone / Interleukin-18 / NF-E2-Related Factor 2 Type of study: Prognostic_studies Language: En Journal: Arthritis Rheum Year: 2012 Type: Article Affiliation country: China

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