3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity.

Moon, Mi Sun; Kang, Boo-Hyon; Krzeminski, Jacek; Amin, Shantu; Aliaga, Cesar; Zhu, Junjia; McDevitt, Emily I; Kocher, Susan; Richie, John P; Isom, Harriet C

Moon, Mi Sun; Kang, Boo-Hyon; Krzeminski, Jacek; Amin, Shantu; Aliaga, Cesar; Zhu, Junjia; McDevitt, Emily I; Kocher, Susan; Richie, John P; Isom, Harriet C.

Affiliation

Moon MS; Department of Microbiology and Immunology, Milton S. Hershey Medical Center, The Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.

Toxicol Sci ; 124(2): 348-58, 2011 Dec.

Article in En | MEDLINE | ID: mdl-21908766

Subject(s)

Acetaminophen/toxicity; Chemical and Drug Induced Liver Injury/prevention & control; Dietary Supplements; Ferrous Compounds/therapeutic use; Iron/metabolism; Liver/drug effects; Analysis of Variance; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury/enzymology; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/pathology; Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP2E1/metabolism; Disease Models, Animal; Ferrous Compounds/administration & dosage; Glutathione/metabolism; Immunohistochemistry; Liver/enzymology; Liver/metabolism; Liver/pathology; Liver Function Tests; Male; Metallocenes; Mice; Mice, Inbred C57BL; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Microsomes, Liver/pathology

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Full text: 1 Database: MEDLINE Main subject: Ferrous Compounds / Dietary Supplements / Chemical and Drug Induced Liver Injury / Iron / Liver / Acetaminophen Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Toxicol Sci Year: 2011 Type: Article Affiliation country: United States

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