Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions.

Schmid, Diethart; Svoboda, Martin; Sorgner, Albin; Moravcevic, Ivana; Thalhammer, Theresia; Chiba, Peter; Möslinger, Thomas

Schmid, Diethart; Svoboda, Martin; Sorgner, Albin; Moravcevic, Ivana; Thalhammer, Theresia; Chiba, Peter; Möslinger, Thomas.

Affiliation

Schmid D; Institute of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Austria. diethart.schmid@meduniwien.ac.at

Life Sci ; 89(19-20): 725-34, 2011 Nov 07.

Article in En | MEDLINE | ID: mdl-21925514

Subject(s)

Anti-Inflammatory Agents/pharmacology; Cytokines/drug effects; Endotoxemia/drug therapy; Glyburide/pharmacology; Potassium Channel Blockers/pharmacology; Adult; Anti-Inflammatory Agents/administration & dosage; Calcium/metabolism; Cytokines/metabolism; Dose-Response Relationship, Drug; Endotoxemia/physiopathology; Glyburide/administration & dosage; Humans; Hypoxia/drug therapy; Hypoxia/physiopathology; Inflammation Mediators/metabolism; KATP Channels/antagonists & inhibitors; Male; Monocytes/metabolism; Potassium Channel Blockers/administration & dosage; RNA, Messenger/metabolism; Receptors, Purinergic P2X7/metabolism; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Cytokines / Glyburide / Endotoxemia / Potassium Channel Blockers / Anti-Inflammatory Agents Type of study: Prognostic_studies Language: En Journal: Life Sci Year: 2011 Type: Article Affiliation country: Austria

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