Silicon analogues of the nonpeptidic GnRH antagonist AG-045572: syntheses, crystal structure analyses, and pharmacological characterization.

Barnes, Matthew J; Burschka, Christian; Büttner, Matthias W; Conroy, Richard; Daiss, Jürgen O; Gray, Ian C; Hendrick, Alan G; Tam, L H; Kuehn, Diana; Miller, David J; Mills, John S; Mitchell, Philip; Montana, John G; Muniandy, Parameswary A; Rapley, Helen; Showell, Graham A; Tebbe, David; Tacke, Reinhold; Warneck, Julie B H; Zhu, Bin

Barnes, Matthew J; Burschka, Christian; Büttner, Matthias W; Conroy, Richard; Daiss, Jürgen O; Gray, Ian C; Hendrick, Alan G; Tam, L H; Kuehn, Diana; Miller, David J; Mills, John S; Mitchell, Philip; Montana, John G; Muniandy, Parameswary A; Rapley, Helen; Showell, Graham A; Tebbe, David; Tacke, Reinhold; Warneck, Julie B H; Zhu, Bin.

Affiliation

Barnes MJ; Paradigm Therapeutics Ltd. (now Takeda Cambridge Ltd.), 418 Cambridge Science Park, Milton Road, Cambridge CB4 0PZ, UK.

ChemMedChem ; 6(11): 2070-80, 2011 Nov 04.

Article in En | MEDLINE | ID: mdl-21953839

Subject(s)

Furans/chemistry; Gonadotropin-Releasing Hormone/antagonists & inhibitors; Hormone Antagonists/chemistry; Hormone Antagonists/pharmacology; Tetrahydronaphthalenes/chemistry; Animals; Crystallography, X-Ray; Drug Evaluation, Preclinical; Furans/pharmacology; Hormone Antagonists/pharmacokinetics; Humans; Luteinizing Hormone/antagonists & inhibitors; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Orchiectomy; Rats, Wistar; Receptors, LHRH/genetics; Silicon/chemistry; Structure-Activity Relationship; Tetrahydronaphthalenes/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Tetrahydronaphthalenes / Gonadotropin-Releasing Hormone / Furans / Hormone Antagonists Language: En Journal: ChemMedChem Year: 2011 Type: Article Affiliation country: United kingdom

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