Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression.

Lin, Yi-Ling; Lin, Rong-Jyh; Shen, Kuo-Pyng; Dai, Zen-Kong; Chen, Ing-Jun; Wu, Jiunn-Ren; Wu, Bin-Nan

Lin, Yi-Ling; Lin, Rong-Jyh; Shen, Kuo-Pyng; Dai, Zen-Kong; Chen, Ing-Jun; Wu, Jiunn-Ren; Wu, Bin-Nan.

Affiliation

Lin YL; Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

J Ethnopharmacol ; 138(2): 373-81, 2011 Nov 18.

Article in En | MEDLINE | ID: mdl-21963569

Subject(s)

Cell Proliferation/drug effects; Endothelin-1/physiology; Flavanones/pharmacology; Muscle, Smooth, Vascular/drug effects; Pulmonary Artery/drug effects; Scutellaria baicalensis/chemistry; TRPC Cation Channels/antagonists & inhibitors; Animals; Calcium/metabolism; Cells, Cultured; Female; Flavanones/isolation & purification; Flow Cytometry; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/metabolism; Protein Kinase C-alpha/antagonists & inhibitors; Pulmonary Artery/cytology; Pulmonary Artery/metabolism; Rats; Rats, Sprague-Dawley; TRPC Cation Channels/metabolism

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Full text: 1 Database: MEDLINE Main subject: Pulmonary Artery / Endothelin-1 / Scutellaria baicalensis / Flavanones / Cell Proliferation / TRPC Cation Channels / Muscle, Smooth, Vascular Language: En Journal: J Ethnopharmacol Year: 2011 Type: Article Affiliation country: Taiwan

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