Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model.

Rathore, Abhay P S; Paradkar, Prasad N; Watanabe, Satoru; Tan, Kah Hin; Sung, Cynthia; Connolly, John E; Low, Jenny; Ooi, Eng Eong; Vasudevan, Subhash G

Rathore, Abhay P S; Paradkar, Prasad N; Watanabe, Satoru; Tan, Kah Hin; Sung, Cynthia; Connolly, John E; Low, Jenny; Ooi, Eng Eong; Vasudevan, Subhash G.

Affiliation

Rathore AP; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore.

Antiviral Res ; 92(3): 453-60, 2011 Dec.

Article in En | MEDLINE | ID: mdl-22020302

Subject(s)

Antiviral Agents/pharmacology; Dengue Virus/drug effects; Dengue/drug therapy; Indolizines/pharmacology; Viral Nonstructural Proteins/metabolism; Animals; Antiviral Agents/administration & dosage; Antiviral Agents/therapeutic use; Cell Line; Cricetinae; Dengue/genetics; Disease Models, Animal; Humans; Indolizines/administration & dosage; Indolizines/therapeutic use; Mice; Mice, 129 Strain; Microbial Sensitivity Tests; Protein Binding; Protein Folding/drug effects; Signal Transduction/drug effects; Unfolded Protein Response/drug effects; Unfolded Protein Response/genetics; Viral Nonstructural Proteins/chemistry

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Antiviral Agents / Viral Nonstructural Proteins / Dengue / Dengue Virus / Indolizines Language: En Journal: Antiviral Res Year: 2011 Type: Article Affiliation country: Singapore

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