Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18.

Conforti-Andreoni, Cristina; Spreafico, Roberto; Qian, Hong Liang; Riteau, Nicolas; Ryffel, Bernhard; Ricciardi-Castagnoli, Paola; Mortellaro, Alessandra

Conforti-Andreoni, Cristina; Spreafico, Roberto; Qian, Hong Liang; Riteau, Nicolas; Ryffel, Bernhard; Ricciardi-Castagnoli, Paola; Mortellaro, Alessandra.

Affiliation

Conforti-Andreoni C; Singapore Immunology Network, Agency for Science, Technology, and Research, Biopolis 138648, Singapore.

J Immunol ; 187(11): 5842-50, 2011 Dec 01.

Article in En | MEDLINE | ID: mdl-22058415

Subject(s)

Cell Differentiation/immunology; Inflammasomes/immunology; Interleukin-18/biosynthesis; Interleukin-1/biosynthesis; Th17 Cells/cytology; Uric Acid/immunology; Adaptive Immunity/immunology; Adjuvants, Immunologic; Animals; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; Coculture Techniques; Dendritic Cells/immunology; Dendritic Cells/metabolism; Enzyme-Linked Immunosorbent Assay; Female; Hemocyanins/immunology; Hemocyanins/pharmacology; Interleukin-1/immunology; Interleukin-18/immunology; Male; Mice; Mice, Inbred C57BL; NF-kappa B/immunology; NF-kappa B/metabolism; Real-Time Polymerase Chain Reaction; Th17 Cells/immunology

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Full text: 1 Database: MEDLINE Main subject: Uric Acid / Cell Differentiation / Interleukin-1 / Interleukin-18 / Th17 Cells / Inflammasomes Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: Singapore

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