Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.

Larsen, Scott D; Wilson, Michael W; Abe, Akira; Shu, Liming; George, Christopher H; Kirchhoff, Paul; Showalter, H D Hollis; Xiang, Jianming; Keep, Richard F; Shayman, James A

Larsen, Scott D; Wilson, Michael W; Abe, Akira; Shu, Liming; George, Christopher H; Kirchhoff, Paul; Showalter, H D Hollis; Xiang, Jianming; Keep, Richard F; Shayman, James A.

Affiliation

Larsen SD; Vahlteich Medicinal Chemistry Core - Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. sdlarsen@umich.edu

J Lipid Res ; 53(2): 282-91, 2012 Feb.

Article in En | MEDLINE | ID: mdl-22058426

Subject(s)

Brain/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Glucosylceramides/metabolism; Glucosyltransferases/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Animals; Brain/metabolism; Cells, Cultured; Dioxanes/chemical synthesis; Dioxanes/pharmacology; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical/methods; Indans/chemical synthesis; Indans/pharmacology; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines/chemistry; Vinblastine/pharmacokinetics

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Brain / Enzyme Inhibitors / Glucosylceramides / Glucosyltransferases Language: En Journal: J Lipid Res Year: 2012 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google