The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study.
Int Urol Nephrol
; 44(3): 689-700, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22081410
ABSTRACT
OBJECTIVE:
It has been shown that coenzyme Q(10) (CoQ(10)) supplementation in men with idiopathic oligoasthenoteratozoospermia (OAT) results in improved semen parameters. In present study, we evaluated the effects of coenzyme CoQ(10) supplementation on semen parameters and pregnancy rates in infertile men with idiopathic OAT. PATIENTS ANDMETHODS:
Two hundred and eighty-seven infertile men with idiopathic OAT were recruited in this study. These patients were treated with CoQ(10) 300 mg orally twice daily for 12 months. Two semen analyses and determination of resting levels of sex hormones were done in all participants. Patients were followed up for another 12 months after CoQ(10) discontinuation.RESULTS:
Mean sperm concentration, sperm progressive motility, and sperm with normal morphology improved significantly after 12-month CoQ(10) therapy by 113.7, 104.8, and 78.9%, respectively (all Ps < 0.05). The overall pregnancy rate was 34.1% within a mean of 8.4 ± 4.7 months.CONCLUSIONS:
CoQ(10) supplementation improves semen quality with beneficial effect on pregnancy rate.
Full text:
1
Database:
MEDLINE
Main subject:
Oligospermia
/
Spermatozoa
/
Vitamins
/
Ubiquinone
/
Pregnancy Rate
/
Infertility, Male
Type of study:
Observational_studies
Language:
En
Journal:
Int Urol Nephrol
Year:
2012
Type:
Article
Affiliation country:
Iran