Danggui Buxue Tang attenuates eosinophil infiltration and airway hyperresponsiveness in asthmatic mice.
Ann Allergy Asthma Immunol
; 107(6): 501-9, 2011 Dec.
Article
in En
| MEDLINE
| ID: mdl-22123379
ABSTRACT
BACKGROUND:
Danggui Buxue Tang (DBT), an herbal formula containing Angelica sinensis (AS) and Astragalus membranaceus (AM) (ASAM = 15, designated as DBT1 here), has been used in Chinese medicine to enhance qi and blood circulation. In addition, DBT has served as a treatment for atopic dermatitis in dogs in Taiwan. It also may improve fibrosis in a rat model of pulmonary fibrosis.OBJECTIVE:
In this study, we evaluated the effect of oral administration of DBT1 in asthma in ovalbumin (OVA)-sensitized mice.METHODS:
Female BALB/c mice were sensitized and challenged with OVA and fed with DBT1 or modified formulas of DBT1, designated as DBT2 (ASAM = 11) and DBT3 (ASAM = 51), from days 21 to 27.RESULTS:
DBT1 suppressed airway hyperresponsiveness and eosinophil infiltration in bronchoalveolar lavage fluid (BALF) and lung, and Th2-associated cytokines and chemokines were inhibited in BALF. In addition, levels of OVA-immunoglobulin E (IgE) also were suppressed in serum. However, treatment with DBT2 or DBT3 showed no improved effects relative to DBT1 in treating asthmatic symptoms.CONCLUSIONS:
These results suggest that orally administered DBT (DBT1) can reduce allergic reactions in OVA-sensitized mice.
Full text:
1
Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Main subject:
Asthma
/
Drugs, Chinese Herbal
/
Bronchial Hyperreactivity
Language:
En
Journal:
Ann Allergy Asthma Immunol
Year:
2011
Type:
Article
Affiliation country:
Taiwan