High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma.

Wang, Xiaoen; Zhang, Liang; Goldberg, S Nahum; Bhasin, Manoj; Brown, Victoria; Alsop, David C; Signoretti, Sabina; Mier, James W; Atkins, Michael B; Bhatt, Rupal S

Wang, Xiaoen; Zhang, Liang; Goldberg, S Nahum; Bhasin, Manoj; Brown, Victoria; Alsop, David C; Signoretti, Sabina; Mier, James W; Atkins, Michael B; Bhatt, Rupal S.

Affiliation

Wang X; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

J Transl Med ; 9: 220, 2011 Dec 21.

Article in En | MEDLINE | ID: mdl-22188900

Subject(s)

Benzenesulfonates/administration & dosage; Benzenesulfonates/therapeutic use; Carcinoma, Renal Cell/drug therapy; Kidney Neoplasms/drug therapy; Pyridines/administration & dosage; Pyridines/therapeutic use; Animals; Antineoplastic Agents/therapeutic use; Carcinoma, Renal Cell/blood supply; Carcinoma, Renal Cell/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Kidney Neoplasms/blood supply; Kidney Neoplasms/pathology; Mice; Mice, Nude; Microvessels/drug effects; Microvessels/pathology; Niacinamide/analogs & derivatives; Perfusion; Phenylurea Compounds; Sorafenib; Treatment Outcome; Xenograft Model Antitumor Assays

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Pyridines / Benzenesulfonates / Carcinoma, Renal Cell / Kidney Neoplasms Type of study: Prognostic_studies Language: En Journal: J Transl Med Year: 2011 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google