Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J Med Chem
; 55(4): 1662-70, 2012 Feb 23.
Article
in En
| MEDLINE
| ID: mdl-22257165
ABSTRACT
The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously described biphenyl methylsulfone hydroxamate series, and they maintain superior Gram-negative antibacterial activity to comparator agents.
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Plantas_medicinales
Main subject:
Pyridones
/
Sulfonic Acids
/
Gram-Negative Bacterial Infections
/
Amidohydrolases
/
Gram-Negative Bacteria
/
Hydroxamic Acids
/
Anti-Bacterial Agents
Language:
En
Journal:
J Med Chem
Year:
2012
Type:
Article
Affiliation country:
United States