Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment--analysis of the age-cardiomyocytes electric capacitance dependence.

Polak, Sebastian; Fijorek, Kamil

Polak, Sebastian; Fijorek, Kamil.

Affiliation

Polak S; Unit of Pharmacoepidemiology and Pharmacoeconomics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Str, 30-688, Cracow, Poland. spolak@cm-uj.krakow.pl

J Cardiovasc Transl Res ; 5(3): 321-32, 2012 Jun.

Article in En | MEDLINE | ID: mdl-22411323

Subject(s)

Aging; Cell Membrane/drug effects; Drug Evaluation, Preclinical/methods; Heart Diseases/chemically induced; Models, Cardiovascular; Models, Statistical; Myocytes, Cardiac/drug effects; Toxicity Tests; Action Potentials; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Cell Membrane/pathology; Child; Child, Preschool; Computer Simulation; Electric Capacitance; Female; Heart Diseases/pathology; Humans; Male; Middle Aged; Myocytes, Cardiac/pathology; Reproducibility of Results; Risk Assessment; Time Factors; Young Adult

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Aging / Cell Membrane / Models, Statistical / Toxicity Tests / Myocytes, Cardiac / Drug Evaluation, Preclinical / Heart Diseases / Models, Cardiovascular Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Cardiovasc Transl Res Year: 2012 Type: Article Affiliation country: Poland

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google